What regulates organ regeneration?

Our well designed systematic biological procedures has always astonished me. How it all is designed? Who is the master mind behind all these? How this system does works so perfectly? Have you ever wondered what to do if there is damage to this system? Yes, organ generation is a possible solution. But do you think all the organs can regenerate?

Medical field has been taking new turns every day. Many advanced techniques, equipment and study have showed up with solutions for many problems. Infact, the medical field has battled with many acute problems like common cold, cough, infections etc. Researchers have perplexed for centuries as to how body parts can regenerate. And the most common uncertainty was about growth of organ. How is size of organ growth defined?

Though humans don’t prominently showcase organ regeneration, but it is very evident in some animals. Thomas Hunt Morgan inspected and analysed the regeneration in planaria and earth worms. Biologists have focused on animals suitable for genetic study and embryonic development.

Animals have three main stratagems to regenerate organs. They are

  1. Multiplication of cells: Normal working cells just don’t divide, they undergo multiplication process. It is the vigorous multiplication of each and every cell which leads to regeneration of the damaged tissues.

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  1. Dedifferentiation: It is a process in which the cells or structures specialised for specific function lose their specialization and become generalised in function. The best example is salamander organ regeneration. When there is any organ damage, the cells replicate and regenerate that part. This is often noticed when they have injured limb reconstitute.
  2. Stem cells: Stem cell is cell of organism which is capable of giving rise to indefinitely more cells of the same type.

These strategies may be of animals but few of these have been employed by humans too. The advanced surgical methods use the stem cell therapy in case of organ transplant. Most commonly for liver healings. The curative cells pass on signals to the remaining cells to recommence the growth. The cells divide and expand the organ back to their size.

As we humans underwent the evolution, we employed similar ways to shape our organs. And our system has so greatly evolved that we developed capacity to heal wounds rapidly to overcome infection.

Untangling the mysteries of regeneration process is truly depending on how we understand the various regeneration procedures differing from animals to humans. But the regeneration has its own draw backs too if not maintained healthily. And how can we infer the correctness of the regenerated part. How to ensure if that part is a t is right orientation and size. Well, researchers can solve these conundrum eventually. But will people be ready to accept it?

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